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Dimethyl Sulfoxide Also known as: DMSO; Dimethylsulphoxide Information on DMSODescription Bioavailability DMSO has the ability to easily pass through every tissue and Cell Membrane of the body except the Teeth, nails and Hair without destroying the integrity of those tissues and Cell Membranes (i.e. it penetrates the membranes without damaging them). DMSO also allows the passage of a number of other compounds across the Cell Membrane Barrier. DMSO is readily absorbed when applied topically onto human Skin, it penetrates within seconds, and peak levels occur after 4-8 hours. Taken Orally, DMSO is also absorbed rather rapidly, and reaches peak levels in the blood after about 4 hours, becoming undetectable after about 120 hours. DMSO leaves the body either UNCHANGED as DiMethylsulphoxide, OR as Dimethylsulphoxone (its metabolite, DMSO2). DMSO2 has a slightly unpleasant garlic odour. Musculoskeletal System DMSO has been used to reduce the harm caused by pulling and/or wrenching muscles, or injuries caused by crushing (such as bruises). It can be used either topically or orally for this purpose, with many people reporting that applying DMSO topically provides faster and more effective results. DMSO has been found to be an effective and powerful scavenger of Hydroxyl Free Radicals.Hydroxyl Free Radicals are considered to be responsible for much of the damage that occurs from bruising injuries, or wrenching or pulling a muscle. In fact, if DMSO is applied to an injury rapidly enough, it is possible to avoid Bruising altogether. DMSO alleviates Rheumatoid Arthritis for some people, by deactivating Hydroxyl Free Radicals, which are one of the causes of the Inflammation and Pain connected with Rheumatoid Arthritis. DMSO is a powerful Pain-Killer, acting by blocking the transmission of Pain Impulses along small Nerve Fibres. Detoxification Research conducted on animals suggests that topically applied DMSO can help protect the body against the toxic effects of X-Rays Excretory System A 50% solution of DMSO applied to the Feet has been observed to alleviate Foot Odour, and observations lead to the conclusion that the longer the solution remains in contact with the foot, the longer-lasting the effectiveness. The FDA in the US has approved DMSO as being suitable for use in the treatment of Interstitial Cystitis. The scientific research behind this approval involved double blind human studies, and a marked improvement in condition was observed in 93% of the patients treated with DMSO. Immune System Another of the properties of DMSO is that it “unfolds” Cell Membranes. “Unfolding” in effect allows more Antigens to attach to the Cell Membranes, and on this contact point they are more efficiently negated by the action of Antibodies. Metabolism Because DMSO combines readily with Hydroxyl Free Radicals, forming Dimethyl Sulphoxone in the process, it effectively neutralizes these Free Radicals and the body excretes them. Respiratory System Sufferers of Sinusitis can open their blocked Sinuses by placing DMSO directly into their nostrils. This action takes only a few minutes to clear the sinuses. Skin Topically applied DMSO can be used to minimize the lesions from Shingles ( Herpes Zoster ). Topical application of DMSO can also be used on skin affected by Scleroderma DMSO Enhances the Function of many Substances DMSO enhances the bioavailability of many substances (it has the capability to transport substances across the body's Cell Membranes without altering the integrity or harming the Cell Membranes in any way). By increasing the bioavailability of these substances, a smaller dosage of these substances can be used. Enzymes DMSO possesses properties similar to Anticholinesterases - i.e. it restricts the release of Cholinesterases Hormones When Steroids such as (but not limited to) Testosterone and Hydrocortisone are dissolved in DMSO, the bio-availability of these steroids increase by as much as three hundred percent. Neurotransmitters GABA or Gamman Aminobutyric Acid has difficulty crossing the Blood-Brain barrier. Pharmaceutical Drugs Because DMSO readily penetrates Cell Membranes without causing harm, it enhances the effectiveness and bio-availability of many pharmaceutical drugs. It facilitates the absorption of penicillins -they can be dissolved in DMSO and applied directly to the skin. Substances that Enhance the Function of DMSO Antioxidants Antioxidants counteract DMSO's tendency to convert to Sulfoxide Free Radicals. Side Effects of DMSO Excretory System DMSO causes Halitosis (temporarily) in the form of a garlic-like odor of the breath. Skin Topical application of DMSO can cause itching, with Skin rashes being another fairly common side effect. The skin’s sensitivity to DMSO varies from person to person, and can usually be avoided by using a more diluted solution of DMSO. DMSO products containing Aloe Vera can also help minimise this unwanted side effect. Myths Dispelled Damage to Eyes There are unfounded fears that DMSO can cause cataracts and other changes in the human eye.While it is not advisable to allow DMSO to contact the eye, the fear that its presence in the body can adversely affect the eye is based on toxicology studies of dogs and rabbits, which show that DMSO does cause damage to the eyes of these animals. However, the toxicity of DMSO to the eyes of dogs and rabbits differs to that of humans. Tests on humans and monkeys showed NO changes to the eye, even with very high dosages of DMSO administered over extended periods of up to two years DMSO as part of the Global Sulfur Cycle The Methyl-S-Methane cycle is responsible for approximately 85% of the bio-available sulfur for all animal and plant life. The cycle is as follows: - Sulfonium Salts > Dimethylsulfide > Dimethyl Sulfoxide (DMSO) > Methylsulfonylmethane (MSM) - Phytoplankton in the seas produce the Sulfonium Salts which in turn produce Dimethylsulfide, a volatile thioether that makes its way into the upper atmosphere. - Dimethylsulfide in the upper atmosphere is oxidised to Dimethylsulfoxide (DMSO) by the catalytic action of Sunlight. - A proportion of the DMSO in the upper atmosphere is oxidised even further by Sunlight to become MSM (Methylsulfonylmethane). - The DMSO and MSM in the upper atmosphere returns to the surface of the earth in raindrops. - Plants absorb the rainwater, and in so doing absorb DMSO and MSM which they use for building Sulfuric compounds. Dosage Recommendations DMSO appears to have a cumulative effect - over time, smaller doses of DMSO are required in order to produce the same effect. Topical Therapeutic Dosage Protocol Topical applications of DMSO should not exceed 70% in areas of the skin affected by poor circulation. It is desirable to commence topical DMSO treatment at low concentrations until Skin tolerance builds up. The Skin must be clean, dry and unbroken before topical application of DMSO. Commercial Availability of DMSO Industrial Grade DMSO Caution: many of the industrial grade DMSO solutions intended for use as solvents have an acid or Acetone contamination of several percent. Acetone contamination can lead to serious medical consequences - because of its small molecular weight, Acetone is readily carried into the blood by Acetone-contaminated DMSO.
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[DMSO INFORMATION] |